Pure® Encapsulations SAMe provides S-adenosylmethionine. S-adenosylmethionine (SAMe) is a naturally occurring compound present in all cells and involved in the synthesis, activation, and metabolism of various molecules. SAMe is a precursor of glutathione, an endogenous molecule that intervenes in the phases of hepatic detoxification. Directions: For those seeking support for detoxification processes. How to use: Take 1 capsule daily between meals. Acid-resistant capsules; do not open before use. Caution: If you are pregnant, breastfeeding, have any health conditions, or are taking any medications, consult your healthcare professional before using this supplement. Conservation: Store in a cool, dry place.